Scientific Articles

  • Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in alpha-mannosidosis
    Damme M, Stroobants S, Walkley SU, Lullmann-Rauch R, D'Hooge R, Fogh J, Saftig P, Lubke T, Blanz, J
    Jour. of neuropathology and experimental neurology, 2011, vol. 70, 83-94
  • Site-specific analysis of N-linked oligosaccharides of recombinant lysosomal arylsulfatase A produced in different cell lines
    Stephan Schröder, Frank Matthes, Pia Hyden, Claes Andersson, Jens Fogh, Sven Müller-Loennies, Thomas Braulke, Volkmar Gieselmann, and Ulrich Matzner
    Glycobiology, 2010, vol. 20 no. 2 pp. 248–259
  • Enzyme replacement improves ataxic gait and central nervous system histopathology in a mouse model of metachromatic leukodystrophy
    Ulrich Matzner, Renate Lüllmann-Rauch, Stijn Stroobants, Claes Andersson, Cecilia Weigelt, Carl Eistrup, Jens Fogh, Rudi D'Hooge and Volkmar Gieselmann
    Molecular Therapy, April 2009, vol. 17, no.4, 600-606
  • Multi-slice Proton MRSI and Clinical Evaluation of Children with Late Infantile Metachromatic Leukodystrophy
    C. i Dali, L.G. Hanson, J. Fogh, U. Haugsted, L. Starup, K. Juul and A.M. Lund
    Poster, International Society for Magnetic Resonance in Medicine, 17th Scientific Meeting, April 18-24, 2009
  • Non-inhibitory antibodies impede lysosomal storage reduction during enzyme replacement therapy of a lysosomal storage disease
    Ulrich Matzner, Frank Matthes, Cecilia Weigelt, Claes Andersson, Carl Eistrup, Jens Fogh and Volkmar Gieselmann
    Journal of Molecular Medicine, 2008, 86: 433-442
  • Reversal of Peripheral and Central Neural Storage and Ataxia after Recombinant Enzyme Replacement Therapy in alpha-Mannosidosis Mice
    Blanz J, Stroobants S, Lüllmann-Rauch R, Morelle W, Lüdemann M, D'Hooge R, Reuterwall H, Michalski JC, Fogh J, Andersson C and Saftig P.
    Human Molecular Genetics, August 2008, Vol. 17, No. 22: 3437-3445
  • Induction of Tolerance to Human Arysulfatase A in a Mouse Model of Metachromatic Leukodystrophy
    Ulrich Matzner, Frank Matthes, Eva Herbst, Renate Lüllmann-Rauch, Zsuzsanna Callaerts-Vegh, Rudi D' Hooge, Cecilia Weigelt, Carl Eistrup, Jens Fogh and Volkmar Gieselmann
    Molecular Medicine, Sept-Oct 2007, 13 (9-10): 1-9 HumanMolecularGenetics
  • Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy
    Ulrich Matzner, Eva Herbst, Kerstin Khalaj Hedayati, Renate Lüllmann-Rauch, Carsten Wessig, Stephan Schröder, Carl Eistrup, Christer Möller, Jens Fogh and Volkmar Gieselmann
    Human Molecular Genetics, 1 May 2005, Vol. 14, No. 9: 1139-1152
  • Efficacy of Enzyme Replacement Therapy in a-Mannosidosis Mice. A Preclinical Animal Study
    Roces, D.P., Lüllmann-Rauch, R., Peng, J., Balducci, C., Andersson, C., Tollersrud, O., Fogh, J., Orlacchio, A., Beccari, T., Saftig, P. and von Figura, K.
    Human Molecular Genetics, 2004, 13, 1979 - 1988
  • Characterization of Porphobilinogen Deaminase Deficient Mice During Phenobarbital Induction of Heme Synthesis and the Effect of Enzyme Replacement
    Johansson, A., Möller, C., Fogh, J. and Harper, P.
    Molecular Medicine, 2003, 9, 5/6, 193-199
  • First clinical trial of I.V. rhPBGD in healthy subjects with and without diagnosed manifest Acute Intermittent Porphyria (AIP)
    Sardh E, Rejkjaer L, Harper P, Andersson D.E.H
    Dept of Internal Medicine, South General Hospital, Stockholm, Sweden, HemeBiotech A/S, Hillerød, Denmark, Porphyria Centre Sweden & Huddinge University Hospital, Stockholm, Sweden
    Porphyrins & Porphyrias 2003, Prague, September 21-24, 2003, Abstracts, Physiol. Res. 2003 Vol.52 23S
  • Overt PCT in a symptomatic AIP patient on hemodialysis
    Sardh E, Harper P, Henrichson A, Möller C, Andersson D.E.H
    Dept of Internal Medicine, South General Hospital, Stockholm, Porphyria Centre Sweden, Huddinge University Hospital, Stockholm & HemeBiotech A/S, Lidingö, Sweden
    Porphyrins & Porphyrias 2003, Prague, September 21-24, 2003, Abstracts, Physiol. Res. 2003 Vol.52 22S
  • Correction of the biochemical defect in porphobilinogen deaminase deficient cells by non-viral gene delivery
    Johansson A, Möller C, Harper P
    Institute for Laboratory Medicine, Porphyria Centre Sweden, Huddinge University Hospital, Stockholm & HemeBiotech A/S, Lidingö, Sweden
    Porphyrins & Porphyrias 2003, Prague, September 21-24, 2003, Abstracts, Physiol. Res. 2003 Vol.52 12S
  • Correlation between plasma and urinary levels of porphobilinogen (PBG) and 5-aminolevulinic acid (ALA) in ten asymptomatic gene carriers of Acute Intermittent Porphyria (AIP) with increased porphyrin precursor excretion
    Harper P, Floderus Y, Andersson C, Möller C, Rejkjaer L, Sardh E, Andersson D.E.H
    Porphyria Centre Sweden, Huddinge University Hospital, Stockholm, Sweden, HemeBiotech A/S, Lidingö, Sweden, HemeBiotech A/S, Hillerød, Denmark & Dept Internal Medicine, South General Hospital, Stockholm, Sweden
    Porphyrins & Porphyrias 2003, Prague, September 21-24, 2003, Abstracts, Physiol. res. 2003 Vol.52 10S
  • Enzyme substitution in a mouse model for metachromatic leukodystrophy, in vivo and in vitro studies
    D. Klein, C. Möller, J. Fogh, V. Gieselmann, U. Matzner
    Institut för Physiologische Chemie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany & HemeBiotech A/S, Hillerød, Denmark
    Posters, 14th ESGLD Workshop, September 18-21, 2003, Pode brady, Czech Republic
  • Correction of the biochemical defect in porphobilinogen deaminase deficient cells by non-viral gene delivery
    Johansson A, Möller C
    Porphyria Centre Sweden, Department of Medical Laboratory Sciences and Technology, Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden & HemeBiotech A/S, Lidingö, SwedeN
    Molecular and Cellular Biochemistry 250: 65-71, 2003
  • Thesis - Correction of the enzymatic and biochemical defect in porphobilinogen deaminase deficient cells by non-viral mediated gene delivery
    Annika Johansson
  • Thesis - Genetic Characterization of Swedish Families with Hereditary Coproporphyria, Variegate Porphyria, and Erythropoietic Protoporphyria
    Åsa Wiman
  • Non-viral mediated gene transfer of porphobilinogen deaminase into mammalian cells
    A. Johansson, C. Möller, P. Gellerfors & P. Harper
    Porphyr ia Centre Sweden, Department of Medical Laboratory Sciences and Technology, Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden & HemeBiotech A/S, Lidingö, Sweden
    Scand J Clin Lab Invest 2002; 62: 105-114
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